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Antigenic Specificity | CD357 (GITR), Human |
Clone | DT5D3 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | purified |
Size | 500 µg in 0.5 mL |
Concentration | n/a |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD357 (GITR) Antibody, anti-human, pure-functional grade. CD357, also known as glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) or TNFRSF18, is an inducible type I transmembrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily. | CD357 is expressed at low levels on thymocyte subsets, resting T cells, B cells, macrophages, and at high levels on CD4+CD25+ regulatory T cells (Tregs). Upon activation, expression on CD4+ and CD8+ T cells is upregulated. Triggering of CD357 has been described to modulate Treg function and costimulate effector T cells. Stimulation of T cells through CD357 can abrogate the inhibitory function of Tregs. It is hypothesized that CD357 has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that CD357 activation may break self-tolerance and induce autoimmunity. | |
Immunogen | n/a |
Other Names | TNFRSF18, AITR, GITR-D |
Gene, Accession # | Gene ID: 8784 |
Catalog # | 130-093-052 |
Price | $515 |
Order / More Info | CD357 (GITR), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Shimizu, J. et al. (2002) Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 3 (2): 135-142. | Nocentini, G. et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94: 6216-6221. | Nocentini, G. et al. (2007) GITR/GITRL: more than an effector T cell co-stimulatory system. Eur. J. Immunol. 37: 1165-1169. | Gurney, A. L. et al. (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9: 215-218. |