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Antigenic Specificity | HLA-A2, A28, Human |
Clone | REA142 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | PerCP-Vio 700 conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | HLA-A2, A28 Antibody, anti-human, PerCP-Vio® 700, REAfinity™. Clone REA142 recognizes HLA A2 and HLA A28, class I human leukocyte antigens (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8-10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. | Additional information: Clone REA142 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | HLA-A |
Gene, Accession # | Gene ID: 3105 |
Catalog # | 130-099-532 |
Price | $360 |
Order / More Info | HLA-A2, A28, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110 (2): 163-169. |