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Antigenic Specificity | NLRX1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: NLRX1 antibody detects endogenous levels of NLRX1. Function: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).Subunit Structure: |
Immunogen | Immunogen: A synthesized peptide derived from human NLRX1. Subcellular Location: Mitochondrion Outer Membrane Tissue Specificity: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level). Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (89%), Dog (100%), Chicken (100%), Xenopus |
Other Names | [Caterpiller protein 11.3; CLR11.3; DLNB26; FLJ21478; MGC131937; MGC21025; NLR family member X1; NLR family, X1; Nlrx1; NLRX1_HUMAN; NOD-like receptor X1; NOD26; NOD5; NOD9; Nucleotide-binding oligomerization domain protein 26; Nucleotide-binding oligomerization domain protein 5; Nucleotide-binding oligomerization domain protein 9; nucleotide-binding oligomerization domain, leucine rich repeat containing X1; Protein Caterpiller 11.3] |
Gene, Accession # | [NLRX1], Gene ID: 79671, NCBI: NP_001269072.1, UniProt: Q86UT6 |
Catalog # | MBS9603352 |
Price | $240, $280 |
Order / More Info | NLRX1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |