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Antigenic Specificity | MDM2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 (1). Aktmediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 (2-4). Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 (3). |
Immunogen | Immunogen: A synthetic -peptide of human MDM2 |
Other Names | [MDM2; MDM2; MDM2; MDM2; HDMX; MGC5370; MGC71221; hdm2;], [MDM2; MDM2; HDMX; hdm2; ACTFS; Hdm2] |
Gene, Accession # | Gene ID: 4193, NCBI: NP_002383.2, UniProt: Q00987 |
Catalog # | MBS125873 |
Price | $275, $430 |
Order / More Info | MDM2 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Haupt, Y. et al. (1997) Nature 387, 296-299. 2. Mayo, L.D. and Donner, D.B. (2001) Proc. Natl. Acad. Sci. USA 98, 11598-11603. 3. Zhou, B. P. et al. (2001) Nat. Cell Biol. 3, 973-981. 4. Grossman, S. R. et al. (1998) Mol. Cell 2, 405-415. |