eIF2B (Ab-67) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityeIF2B (Ab-67)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse
Isotypen/a
Formatimmunogen affinity purified
Size0.05 mL, 0.1 mL
Concentration1.0 mg/ml
ApplicationsWestern Blot (WB)
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DescriptionThe antibody detects endogenous levels of total eIF2B protein. eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.Pathak V.K., Cell 54:633-639(1988).Deloukas P., Nature 414:865-871(2001).Olsen J.V., Cell 127:635-648(2006).
ImmunogenImmunogen Type: Peptide Immunogen Description: Synthesized peptide derived from N-terminal of human eIF2B.
Other Names[DKFZp686L18198; eIF-2-beta; EIF2; EIF2B; EIF2beta]
Gene, Accession #[eIF2B], Gene ID: 8894, NCBI: NP_003899.2, UniProt: P20042
Catalog #MBS9413448
Price$200, $255
Order / More InfoeIF2B (Ab-67) Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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