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Antigenic Specificity | eIF2B (Ab-67) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total eIF2B protein. eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.Pathak V.K., Cell 54:633-639(1988).Deloukas P., Nature 414:865-871(2001).Olsen J.V., Cell 127:635-648(2006). |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from N-terminal of human eIF2B. |
Other Names | [DKFZp686L18198; eIF-2-beta; EIF2; EIF2B; EIF2beta] |
Gene, Accession # | [eIF2B], Gene ID: 8894, NCBI: NP_003899.2, UniProt: P20042 |
Catalog # | MBS9413448 |
Price | $200, $255 |
Order / More Info | eIF2B (Ab-67) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |