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Antigenic Specificity | AIFM3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-AIFM3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with AIFM3 from other sources has not been determined. Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist. |
Immunogen | Anti-AIFM3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the N-terminus of human AIFM3. |
Other Names | AIFM3 Antibody, AIFL, AIFL, Apoptosis-inducing factor 3, Apoptosis-inducing factor-like protein |
Gene, Accession # | AIFM3, Gene ID: 150209, NCBI: NP_001018070.1, UniProt: Q96NN9 |
Catalog # | 600-401-X85 |
Price | $475 |
Order / More Info | AIFM3 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |