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Product Name | MK-0591 |
Description | An inhibitor of FLAP (IC50 = 1.6 nM for the human enzyme); inhibits LTB4 biosynthesis in A23187-stimulated isolated rat neutrophils (IC50 = 6 nM) but does not inhibit 5-LO in a cell-free assay (IC50 = > 4 µM for the rat enzyme); prevents increases in airway resistance and decreases in dynamic compliance in Ascaris antigen-induced squirrel monkeys at 0.3 and 1 mg/kg; decreases proteinuria and reduces decreases in renal LTC4 synthase activity in a rat model of nephrotoxic rabbit serum-induced glomerulonephritis at 60 mg/kg; induces apoptosis in LNCaP cells at 8 µM |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | L-686,708|Quiflapon |
Gene, Accession, CAS # | CAS: 136668-42-3 |
Catalog # | 37322-5 |
Price | $299.00 |
Order / More Info | MK-0591 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |