Edit |   |
---|---|
Product Name | MK-0974 |
Description | A CGRP receptor antagonist (Ki = 0.77 µM); binds selectively to the human CGRP receptor complex over the adrenomedullin receptor complexes in HEK293 cells (Kis = >100 and 29 µM for CRLR with RAMP2 and 3, respectively); inhibits CGRP-induced cAMP accumulation in HEK293 cells expressing the CGRP receptor complex (IC50 = 2.2 nM); reduces CGRP-induced vasodilation in isolated human meningeal arteries; inhibits vasodilation induced by topical application of capsaicin in rhesus monkeys (EC50 = 127 nM) |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | MK0974 telcagepant RAMP-1 2 3 HEK-293 |
Gene, Accession, CAS # | CAS: 781649-09-0 |
Catalog # | 23960-10 |
Price | $535.00 |
Order / More Info | MK-0974 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |