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Antigenic Specificity | TNF Receptor-Associated Factor 6 (TRAF6) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq]. |
Immunogen | KLH-conjugated synthetic peptide between 314-343 amino acids from the Central region of human TRAF6. |
Other Names | RNF85, TNF receptor-associated factor 6, E3 ubiquitin-protein ligase TRAF6, Interleukin-1 signal transducer, RING finger protein 85, TNF Receptor Associated Factor 6, TRAF6, TRAF 6, TRAF-6, MGC:3310, RNF85, RNF85, RNF85 , RNF85 , TNF receptor-associated factor 6, TNF receptor-associated factor 6, TNF receptor-associated factor 6 , TNF receptor-associated factor 6 , E3 ubiquitin-protein ligase TRAF6, E3 ubiquitin-protein ligase TRAF6, E3 ubiquitin-protein ligase TRAF6 , E3 ubiquitin-protein ligase TRAF6 , Interleukin-1 signal transducer, Interleukin-1 signal transducer, Interleukin-1 signal transducer , Interleukin-1 signal transducer , RING finger protein 85, RING finger protein 85, RING finger protein 85 , RING finger protein 85 , TNF Receptor Associated Factor 6, TNF Receptor Associated Factor 6, TNF Receptor Associated Factor 6 , TNF Receptor Associated Factor 6 , TRAF6, TRAF6, TRAF6 , TRAF6 , TRAF 6, TRAF 6, TRAF 6 , TRAF 6 , TRAF-6, TRAF-6, TRAF-6 , TRAF-6 , MGC:3310, MG |
Gene, Accession # | TRAF6, UniProt: Q9Y4K3 |
Catalog # | abx031071 |
Price | please inquire |
Order / More Info | TNF Receptor-Associated Factor 6 (TRAF6) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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