WW Domain Containing Transcription Regulator Protein 1 (WWTR1) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-WW Domain Containing Transcription Regulator Protein 1 (WWTR1) antibody, protein, ELISA kits.
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| Antigenic Specificity | WW Domain Containing Transcription Regulator Protein 1 (WWTR1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. |
| Immunogen | KLH-conjugated synthetic peptide between 370-398 amino acids from the C-terminal region of human WWTR1. |
| Other Names | DKFZP586I1419, FLJ27004, FLJ45718, OTTHUMP00000215994, OTTHUMP00000215995, OTTHUMP00000215996, OTTHUMP00000216001, TAZ, Transcriptional co activator with PDZ binding motif, Transcriptional coactivator with PDZ binding motif, Transcriptional coactivator with PDZ-binding motif, WW domain containing transcription regulator 1, WW domain containing transcription regulator protein 1, WW domain-containing transcription regulator protein 1, WWTR 1, WWTR1, DKFZP586I1419, DKFZP586I1419, DKFZP586I1419 , DKFZP586I1419 , FLJ27004, FLJ27004, FLJ27004 , FLJ27004 , FLJ45718, FLJ45718, FLJ45718 , FLJ45718 , OTTHUMP00000215994, OTTHUMP00000215994, OTTHUMP00000215994 , OTTHUMP00000215994 , OTTHUMP00000215995, OTTHUMP00000215995, OTTHUMP00000215995 , OTTHUMP00000215995 , OTTHUMP00000215996, OTTHUMP00000215996, OTTHUMP00000215996 , OTTHUMP00000215996 , OTTHUMP00000216001, OTTHUMP00000216001, OTTHUMP00000216001 , OTTHUMP00000216001 , TAZ, TAZ, TAZ , TAZ , Transcriptional co activator with PDZ bindin |
| Gene, Accession # | WWTR1, UniProt: Q9GZV5 |
| Catalog # | abx028805 |
| Price | please inquire |
| Order / More Info | WW Domain Containing Transcription Regulator Protein 1 (WWTR1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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