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Antigenic Specificity | FK506 Binding Protein 4 (FKBP4) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB, FCM |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | FKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. |
Immunogen | KLH-conjugated synthetic peptide between 186-216 amino acids from the Central region of human FKBP4. |
Other Names | FKBP4, FKBP52, Peptidyl-prolyl cis-trans isomerase FKBP4, 51 kDa FK506-binding protein, 52 kDa FK506-binding protein, 59 kDa immunophilin, FK506-binding protein 4, FKBP59, HSP-binding immunophilin, Immunophilin FKBP52, Rotamase, N-terminally processed, PPIase FKBP4, FKBP51, 52 kDa FKBP, FKBP-52, p59, FKBP-4, HBI, p52, Hsp56, PPIase, FKBP4, FKBP4, FKBP4 , FKBP4 , FKBP52, FKBP52, FKBP52 , FKBP52 , Peptidyl-prolyl cis-trans isomerase FKBP4, Peptidyl-prolyl cis-trans isomerase FKBP4, Peptidyl-prolyl cis-trans isomerase FKBP4 , Peptidyl-prolyl cis-trans isomerase FKBP4 , 51 kDa FK506-binding protein, 51 kDa FK506-binding protein, 51 kDa FK506-binding protein , 51 kDa FK506-binding protein , 52 kDa FK506-binding protein, 52 kDa FK506-binding protein, 52 kDa FK506-binding protein , 52 kDa FK506-binding protein , 59 kDa immunophilin, 59 kDa immunophilin, 59 kDa immunophilin , 59 kDa immunophilin , FK506-binding protein 4, FK506-binding protein 4, FK506-binding protein 4 , FK506-binding |
Gene, Accession # | UniProt: Q02790 |
Catalog # | abx033367 |
Price | please inquire |
Order / More Info | FK506 Binding Protein 4 (FKBP4) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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