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Antigenic Specificity | Granulin (GRN) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 20 µl, 50 µl, 100 µl, 200 µl |
Concentration | > 0.5 mg/ml |
Applications | WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | GRN antibody is a Rabbit polyclonal antibody against GRN. Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. |
Immunogen | Recombinant protein of human GRN. |
Other Names | GEP, GP88, PEPI, PGRN, CLN11, PCDGF, Granulins, Glycoprotein of 88 Kda, Progranulin, Granulin G, Granulin F, Granulin B, Granulin A, Granulin C, Granulin D, Granulin E, GRN, Acrogranin, Epithelin precursor, Granulin, Granulin-epithelin, PC cell-derived growth factor, Proepithelin, Paragranulin, Granulin-1, Granulin-2, Granulin-3, Granulin-4, Granulin-5, Granulin-6, Granulin-7, GEP, GEP, GEP , GEP , GP88, GP88, GP88 , GP88 , PEPI, PEPI, PEPI , PEPI , PGRN, PGRN, PGRN , PGRN , CLN11, CLN11, CLN11 , CLN11 , PCDGF, PCDGF, PCDGF , PCDGF , Granulins, Granulins, Granulins , Granulins , Glycoprotein of 88 Kda, Glycoprotein of 88 Kda, Glycoprotein of 88 Kda , Glycoprotein of 88 Kda , Progranulin, Progranulin, Progranulin , Progranulin , Granulin G, Granulin G, Granulin G , Granulin G , Granulin F, Granulin F, Granulin F , Granulin F , Granulin B, Granulin B, Granulin B , Granulin B , Granulin A, Granulin A, Granulin A , Granulin A , Granulin C, Granulin C, Granulin C , Granulin C |
Gene, Accession # | GRN, Gene ID: 2896, UniProt: P28799 |
Catalog # | abx004421 |
Price | please inquire |
Order / More Info | Granulin (GRN) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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