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Antigenic Specificity | Serine/threonine-Protein Kinase Chk1 (CHK1) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger. |
Immunogen | KLH-conjugated synthetic peptide between 258-287 amino acids from human CHK1. |
Other Names | Checkpoint, S. pombe, homolog of, 1, CHEK1, CHK1, CHK1 checkpoint homolog (S. pombe), Serine/threonine-protein kinase Chk1, kinase Chk1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, Checkpoint, Checkpoint, Checkpoint , Checkpoint , S. pombe, S. pombe, S. pombe , S. pombe , homolog of, homolog of, homolog of , homolog of , 1, 1, 1 , 1 , CHEK1, CHEK1, CHEK1 , CHEK1 , CHK1, CHK1, CHK1 , CHK1 , CHK1 checkpoint homolog (S. pombe), CHK1 checkpoint homolog (S. pombe), CHK1 checkpoint homolog (S. pombe) , CHK1 checkpoint homolog (S. pombe) , Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk1 , Serine/threonine-protein kinase Chk1 , kinase Chk1, kinase Chk1, kinase Chk1 , kinase Chk1 , CHK1 checkpoint homolog, CHK1 checkpoint homolog, CHK1 checkpoint homolog , CHK1 checkpoint homolog , Cell cycle checkpoint kinase, Cell cycle checkpoint kinase, Cell cycle checkpoint kinase , Cell cycle checkp |
Gene, Accession # | NCBI: NP_001107593.1, NP_001107594.1, NP_001231775.1, NP_001265.2, UniProt: O14757 |
Catalog # | abx031571 |
Price | please inquire |
Order / More Info | Serine/threonine-Protein Kinase Chk1 (CHK1) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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