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Antigenic Specificity | Nicastrin (NCSTN) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 20 µl, 50 µl, 100 µl, 200 µl |
Concentration | > 0.5 mg/ml |
Applications | WB, IF/ICC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | NCSTN antibody is a Rabbit polyclonal antibody against NCSTN. This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. |
Immunogen | Recombinant protein of human NCSTN. |
Other Names | APH2, RP11-517F10.1, NCSTN, KIAA0253, APH2, APH2, APH2 , APH2 , RP11-517F10.1, RP11-517F10.1, RP11-517F10.1 , RP11-517F10.1 , NCSTN, NCSTN, NCSTN , NCSTN , KIAA0253, KIAA0253, KIAA0253 , KIAA0253 |
Gene, Accession # | NCSTN, Gene ID: 23385, UniProt: Q92542 |
Catalog # | abx000564 |
Price | please inquire |
Order / More Info | Nicastrin (NCSTN) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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