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Antigenic Specificity | Neuroendocrine Secretory Protein 55 (GNAS) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC, IF/ICC, FCM |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activati?n?o? ?d?n?l?l?cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. |
Immunogen | KLH-conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human GNAS. |
Other Names | GNAS, GNAS Complex Locus, Guanine Nucleotide Binding Protein (G Protein), Alpha Stimulating Activity Polypeptide 1, Guanine Nucleotide-Binding Protein G(S) Subunit Alpha Isoforms XLas, Adenylate Cyclase-Stimulating G Alpha Protein, Alternative Gene Product Encoded By XL-Exon, Extra Large Alphas Protein, G Protein Subunit Alpha S, Secretogranin VI, Protein ALEX, GNAS1, GSP, Guanine Nucleotide-Binding Protein G(S) Subunit Alpha Isoforms Short, Guanine Nucleotide Regulatory Protein, Neuroendocrine Secretory Protein 55, Neuroendocrine Secretory Protein, Protein SCG6 (Secretogranin VI), NONHSAG032159, HSALNG0131287, Protein GNAS, C20orf45, XLalphas, NESP55, PITA3, GPSA, NESP, SCG6, SgVI, AHO, GSA, POH, GNAS, GNAS, GNAS , GNAS , GNAS Complex Locus, GNAS Complex Locus, GNAS Complex Locus , GNAS Complex Locus , Guanine Nucleotide Binding Protein (G Protein), Alpha Stimulating Activity Polypeptide 1, Guanine Nucleotide Binding Protein (G Protein), Alpha Stimulating Activity Polypeptide 1, Gu |
Gene, Accession # | UniProt: Q5FWY2 |
Catalog # | abx025024 |
Price | please inquire |
Order / More Info | Neuroendocrine Secretory Protein 55 (GNAS) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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