Toll-Like Receptor 7 (TLR7) Antibody from ABBEXA LTD
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| Antigenic Specificity | Toll-Like Receptor 7 (TLR7) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 100 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TLR7 antibody is a Rabbit polyclonal antibody against TLR7. Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responsesTLRs recognize conserved motifs found in various pathogens and mediate defense responsesTriggering of the TLR pathway leads to the activation of NF-?B and subsequent regulation of immune and inflammatory genesThe TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domainUpon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule)This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKKActivation of IKK leads to the degradation of I?B that normally maintains NF-?B inactivity by sequestering it in the cytoplasmTLR7, 8 and 9 form a group of structurally related TLR family members that are are localized to intracellular endosomesTLR7 shows highest expression in lung, placenta, and spleenTLR7 mediates responses to a class of synthetic compounds, including imidazoquinolines, guanosine-based drugs that induce anti-viral responsesNaturally, TLR7 responds to ssRNA viruses to activate NF-?B and trigger IFN production. |
| Immunogen | Recombinant protein of human TLR7. |
| Other Names | TLR7, Toll-like receptor 7, UNQ248/PRO285, TLR7, TLR7, TLR7 , TLR7 , Toll-like receptor 7, Toll-like receptor 7, Toll-like receptor 7 , Toll-like receptor 7 , UNQ248/PRO285, UNQ248/PRO285, UNQ248/PRO285 , UNQ248/PRO285 |
| Gene, Accession # | TLR7, Gene ID: 51284, UniProt: Q9NYK1 |
| Catalog # | abx117019 |
| Price | please inquire |
| Order / More Info | Toll-Like Receptor 7 (TLR7) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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