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Antigenic Specificity | THO Complex 6 (THOC6) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4. |
Immunogen | KLH-conjugated synthetic peptide between 96-123 amino acids from the Central region of human THOC6. |
Other Names | THOC6, WDR58, THO complex subunit 6 homolog, Functional spliceosome-associated protein 35, WD repeat-containing protein 58, THOC6, THOC6, THOC6 , THOC6 , WDR58, WDR58, WDR58 , WDR58 , THO complex subunit 6 homolog, THO complex subunit 6 homolog, THO complex subunit 6 homolog , THO complex subunit 6 homolog , Functional spliceosome-associated protein 35, Functional spliceosome-associated protein 35, Functional spliceosome-associated protein 35 , Functional spliceosome-associated protein 35 , WD repeat-containing protein 58, WD repeat-containing protein 58, WD repeat-containing protein 58 , WD repeat-containing protein 58 |
Gene, Accession # | THOC6, UniProt: Q86W42 |
Catalog # | abx030427 |
Price | please inquire |
Order / More Info | THO Complex 6 (THOC6) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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