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Antigenic Specificity | CHK1 (pS317) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC, DB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Checkpoint pathways control the order and timing of cell cycle transitions and ensure that critical events, such as DNA replication and chromosome segregation, are completed with high fidelity. The S. pombe Chk1 gene encodes a protein kinase that is required for the DNA damage checkpoint. Antibodies against CHK1 recognized a 54-kD protein on immunoblots of mammalian cell extracts. However, CHK1 is modified in response to DNA damage. In vitro, CHK1 directly phosphorylated a regulator of CDC2 tyrosine phosphorylation, CDC25C. In response to DNA damage, CHK1 phosphorylates and inhibits CDC25C, thus preventing activation of the CDC2-cyclin B complex and mitotic entry. CHK1 directly phosphorylates CDC25A during an unperturbed cell cycle, and that phosphorylation of CDC25A by CHK1 is required for cells to delay cell cycle progression in response to double-strand DNA breaks. |
Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S317 of human CHK1. |
Other Names | Checkpoint, S. pombe, homolog of, 1, CHEK1, CHK1, CHK1 checkpoint homolog (S. pombe), Serine/threonine-protein kinase Chk1, kinase Chk1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, Checkpoint, Checkpoint, Checkpoint , Checkpoint , S. pombe, S. pombe, S. pombe , S. pombe , homolog of, homolog of, homolog of , homolog of , 1, 1, 1 , 1 , CHEK1, CHEK1, CHEK1 , CHEK1 , CHK1, CHK1, CHK1 , CHK1 , CHK1 checkpoint homolog (S. pombe), CHK1 checkpoint homolog (S. pombe), CHK1 checkpoint homolog (S. pombe) , CHK1 checkpoint homolog (S. pombe) , Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk1 , Serine/threonine-protein kinase Chk1 , kinase Chk1, kinase Chk1, kinase Chk1 , kinase Chk1 , CHK1 checkpoint homolog, CHK1 checkpoint homolog, CHK1 checkpoint homolog , CHK1 checkpoint homolog , Cell cycle checkpoint kinase, Cell cycle checkpoint kinase, Cell cycle checkpoint kinase , Cell cycle checkp |
Gene, Accession # | UniProt: O14757 |
Catalog # | abx031852 |
Price | please inquire |
Order / More Info | CHK1 (pS317) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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