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Antigenic Specificity | Mothers Against Decapentaplegic Homolog 2 (SMAD2) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human, mouse, rat, cow |
Isotype | IgG1 |
Format | ascites |
Size | 100 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC, IF/ICC, FCM |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C.elegans gene Sma.SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation.This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein.In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors.The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4.The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors.This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.Alternatively spliced transcript variants encoding the same protein have been observed. |
Immunogen | Purified recombinant fragment of human SMAD2 expressed in E. coli. |
Other Names | JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, MGC22139, MGC34440, Mad-related protein 2, Mothers against DPP homolog 2, Mothers against, Mothers against decapentaplegic homolog 2, Smad 2, MAD homolog 2, SMAD family member 2, Smad2, SMAD3, MADH3, Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, hSMAD3, V18, JV18, JV18, JV18 , JV18 , MADH2, MADH2, MADH2 , MADH2 , MADR2, MADR2, MADR2 , MADR2 , JV18-1, JV18-1, JV18-1 , JV18-1 , hMAD-2, hMAD-2, hMAD-2 , hMAD-2 , hSMAD2, hSMAD2, hSMAD2 , hSMAD2 , MGC22139, MGC22139, MGC22139 , MGC22139 , MGC34440, MGC34440, MGC34440 , MGC34440 , Mad-related protein 2, Mad-related protein 2, Mad-related protein 2 , Mad-related protein 2 , Mothers against DPP homolog 2, Mothers against DPP homolog 2, Mothers against DPP homolog 2 , Mothers against DPP homolog 2 , Mothers against, Mothers against, Mothers against , Mothers against , Mothers against decapentapleg |
Gene, Accession # | Gene ID: 4087, 17126, 29357, 516010 |
Catalog # | abx015993 |
Price | please inquire |
Order / More Info | Mothers Against Decapentaplegic Homolog 2 (SMAD2) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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