Abeta 40 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | Abeta 40 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 200 µL |
| Concentration | 2 mg/mL |
| Applications | Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1). This antibody can recogniaze the N-terminus of human APP: Soluble APP-alpha and Soluble APP-beta. Target Information: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
| Immunogen | Recombinant Human Beta-amyloid 40 protein |
| Other Names | AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|alzheimer disease amyloid protein|amyloid beta A4 protein|beta-amyloid peptide|cerebral vascular amyloid peptide|peptidase nexin-II|preA4|protease nexin-II|amyloid beta precursor protein|APP|Amyloid beta 40|Abeta 40|AG|alzheimer disease amyloid A4 protein homolog|amyloid A4|amyloidogenic glycoprotein|amyloid beta (A4) precursor protein (peptidase nexin-II|Alzheimer disease)|amyloid precursor protein|Adap|E030013M08Rik|betaApp|appican|protease nexin II|amyloid beta (A4) precursor protein |
| Gene, Accession # | Gene ID: 11820, 54226 |
| Catalog # | ABIN7233690 |
| Price | $473 |
| Order / More Info | Abeta 40 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
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