SOD1 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | SOD1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Atto 488 conjugate |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Immunohistochemistry, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (2). It works by catalyzing the dismutation of the superoxide radical O2E to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (1,4). In general, SODs play a major role in antioxidant defense mechanisms (3). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (2). Misfolding of SOD1 has been implicated in Amyotrophic lateral sclerosis (ALS). Therefore conformation specific antibodies such as SOD1 (EDI), which targets an exposed region of the dimer interface (EDI) of SOD1, are useful for determining the conformation of SOD1 in affected tissues (5). This antibody can be used in conjunction with SOD1 (UβB) (SPC-205D) which detects an unfolded beta barrel (UβB) of SOD1. Target Information: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]. |
| Immunogen | C-terminal region of SOD1, exposed dimer interface (EDI) |
| Other Names | LOC692639|Cun SOD|Cu/Zn superoxide dismutase|SOD|Superoxide Dismutase 1, Soluble|SOD1|ALS|ALS1|IPOA|hSod1|homodimer|Cun superoxide dismutase|soluble|indophenoloxidase A|superoxide dismutase Cu-Zn|superoxide dismutase|cystolic|superoxide dismutase 1|CG11793|Cu|Cu-Zn SOD|CunSOD|CuSOD|CuZn SOD|CuZn-SOD|CuZn-SOD1|CuZnSOD|Cu2+n2+SOD|DmelCG11793|G|Mn SOD|SOD-1|To|To-1|Zn SOD|Zn-SOD|ZnSod|cSOD|dSOD1|l(3)108|l(3)68Af'|l(3)G|CG11793-PA|CG11793-PD|Zn superoxide dismutase|Cu-Zn superoxide dismutase|Cun-Superoxide dismutase|CuZn superoxide dismutase|CuZn-superoxide dismutase|CuZn-superoxide dismutase (SOD)1|Cu2+ Zn2+ superoxide dismutase|Cu2+Zn2+ superoxide dismutase|Mn superoxide dismutase|Sod-PA|Sod-PD|complementation group G|copper and zinc SOD|copper-zinc superoxide|copper-zinc superoxide dismutase|cytoplasmic CunSOD|dismutase|super oxide dismutase|superoxidase dismutase|superoxide dismutatase|superoxide-dismutase|superoxido dismutase|tetrazolium oxidase|tetrazolium oxidase-1|soluble (amyotrophic lateral sclerosis 1 (adult))|CUN-SOD|SODC|superoxide dismutase 1 soluble|DKFZP469M1833|superoxide dismutase 1 S homeolog|sod1.S|B430204E11Rik|Ipo-1|Ipo1|Cu(2+)-Zn2+ superoxide dismutase|Cu-Zn-superoxide dismutase|SOD1L1|Superoxide dismutase [Cu-Zn]|Zn-superoxide dismutase|XSODB|sod1-a|superoxide dismutase Cu-Zn B|superoxide dismutase 1 L homeolog|sod1.L|LOC101115136|ZSOD|cuzn|sod(Cun)|superoxide dismutase Sod1 |
| Gene, Accession # | Gene ID: 6647 |
| Catalog # | ABIN2486216 |
| Price | $551 |
| Order / More Info | SOD1 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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