HLA-ABC Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | HLA-ABC |
| Clone | polyclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 500 µg |
| Concentration | n/a |
| Applications | Positive Control |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | anti-human HLA-ABC monoclonal antibody recognizes an epitope common among 43 kDa chains of the HLA-ABC antigens. These antigens appear on virtually every human nucleated cell. This antibody is suitable as a positive control for HLA tissue typing and crossmatching Target Information: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]. |
| Immunogen | Purified membrane of human tonsil cells . Fusion Partner: NS1/1-Ag4.1 . Donor: BALB/c spleen |
| Other Names | HLAA|HLA class I histocompatibility antigen|A-1 alpha chain|MHC class I antigen HLA-A heavy chain|antigen presenting molecule|leukocyte antigen class I-A|major histocompatibility complex, class I, A|HLA-A|HLA-ABC |
| Gene, Accession # | Gene ID: 3105 |
| Catalog # | ABIN134294 |
| Price | $456 |
| Order / More Info | HLA-ABC Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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52072 Aachen GERMANY
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