ZNF451 Antibody from BIOLEGEND

ZNF451, or Zinc finger protein 451, exhibits E3 SUMO ligase activity along with zinc finger domains that regulate biological processes. These processes include sumoylation, TGF-β signaling, and the stability of promyelocytic leukemia (PML) bodies within the nucleus. ZNF451 contains sumo-related domains which enables SUMO-protein ligase activity and interaction with SUMO 2. In mouse models, the sumoylation of PML proteins by ZNF451 decreases the stability of PML bodies. In addition, in response to cellular stressors such as topoisomerase 2 (TOP2) activity and DNA damage, ZNF451 binds to TOP2 leading to the recruitment of TDP2. This recruitment facilitates the unloading of the TOP2 cleavage complex to regulate DNA repair mechanisms. The zinc finger domains of ZNF451 effectively bind to SMAD2/3/4 proteins and attenuate upstream TGF-β signals. This interaction results in the repression of transcriptional activity, thereby influencing downstream cellular processes.