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Antigenic Specificity | Beclin-1 |
Clone | O93F3 |
Host Species | Mouse |
Reactive Species | human, rat, mouse |
Isotype | IgG1, κ |
Format | purified |
Size | 100 µg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Purified anti-Beclin-1. Beclin-1 plays a central role in autophagy and is involved in autophagosome formation. It acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Beclin-1 is necessary for the initiation of autophagy, and it has been shown to be reduced in the brains of patients with Alzheimer's disease. Reduced Beclin-1 levels lead to decreased autophagy, the accumulation of Aβ peptides, and neurodegeneration in mouse models of Alzheimer?s disease. |
Immunogen | Full length recombinant human Beclin-1 protein (NP_003757) produced in HEK293T cells |
Other Names | ATG6 Autophagy Related 6 Homolog, VSP30 |
Gene, Accession # | Gene ID: 8678 |
Catalog # | 849702 |
Price | $288 |
Order / More Info | Beclin-1 Antibody from BIOLEGEND |
Product Specific References | n/a |