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Antigenic Specificity | PTEN |
Clone | 4C11A11 |
Host Species | Mouse |
Reactive Species | human, mouse |
Isotype | IgG2b, κ |
Format | purified |
Size | 100 µg |
Concentration | n/a |
Applications | Western Blot (WB), ICC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Purified anti-PTEN. PTEN was discovered as a tumor suppressor with lipid and protein phosphatase activity. Heterozygous loss of PTEN in mice contribute to the development of a variety of types of cancer, suggesting that insufficient PTEN activity results in increased cancer susceptibility. PTEN negatively regulates the PI3K/AKT pathway by dephosphorylating the second messenger phosphoinositide 3,4,5-triphosphate (PIP3) produced by phosphoinositide 3-kinase (PI3K), which results in inhibition of abnormal cell prolif |
Immunogen | Partial human PTEN recombinant protein (303-403aa) |
Other Names | MMAC1, BZS, TEP1, MHAM1, GLM2, PTEN1 |
Gene, Accession # | Gene ID: 5728 |
Catalog # | 655002 |
Price | $265 |
Order / More Info | PTEN Antibody from BIOLEGEND |
Product Specific References | PubMed: 30736829, 32736533 |