Description | PE anti-mouse FOXP3. FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4 /CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in ?sc |
Product Specific References | PubMed: 19915047, 20335532, 24443555, 22532866, 24416230, 26841120, 26846186, 27816922, 30420782, 30926232, 30926232, 30287389, 30626941, 31613799, 30850480, 32398953, 32220307, 31413910, 32988398, 32692155, 33446805, 33593403, 33593403, 33357448, 33761313, 33826903 |