Description | APC anti-human CD80. CD80, also known as B7-1, B7, and BB1, is a 60 kD single chain type I glycoprotein belonging to the immunoglobulin superfamily. CD80 is expressed on activated B and T cells, macrophages, and dendritic cells. CD80 binds to CD28 and CD152 (CTLA-4). Along with CD86, CD80 plays a critical role in regulation of T cell activation. The interaction of CD80 with CD28 provides a potent costimulatory signal for T cell activation through the CD3 complex, while its interaction with CTLA-4 provides an inhibit |
Product Specific References | PubMed: 23936476, 25295996, 25348634, 26416279, 26918785, 27806101, 29399416, 30355498, 29894690, 30723479, 30850595, 29894690, 30355498, 31757674, 32195350, 32210962, 29093026, 32997691, 32370596, 33904395 |