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Antigenic Specificity | Human ACE2 |
Clone | 4G8C11 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, κ |
Format | purified |
Size | 100 µg |
Concentration | n/a |
Applications | Flow Cytometry (FC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Purified anti-human ACE2. Angiotensin-converting enzyme 2 (ACE2) is a type one transmembrane protein, which shares approximately 60% homology with ACE. The predicted human ACE2 protein sequence consists of 805 amino acids, including an N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE2 catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7 involved in vasoconstriction. ACE2 has been shown to be a functional receptor for the spike glycoprotein of the human coronavirus, HCoV-NL63, and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2. Based on recent single-cell RNA sequencing database, high ACE2 RNA expression was identified in the lung, esophagus, kidney, intestine, bile duct, heart, testis, endothelial cells, and vascular smooth muscle cells. |
Immunogen | n/a |
Other Names | Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACE-2, ACEH |
Gene, Accession # | Gene ID: 59272 |
Catalog # | 342752 |
Price | $315 |
Order / More Info | Human ACE2 Antibody from BIOLEGEND |
Product Specific References | n/a |