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Antigenic Specificity | Human IRF1 |
Clone | W17068C |
Host Species | Rat |
Reactive Species | human |
Isotype | IgG2a, κ |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests |
Concentration | n/a |
Applications | Intracellular Staining for Flow Cytometry (ICFC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PE anti-human IRF1. IRF1 is the first identified member of the interferon regulatory transcription factor family. Its expression is induced in response to pathogen infection or the stimulation of several cytokines, including type I and II IFN, IL-1, IL-6, and TNF-α. Upon stimulation, IRF1 is transcriptionally activated by STAT1 and NFκB transcription factors via the GAS (interferon-gamma-activated sequence) element in the IRF1 promoter. IRF1 plays important roles in mediating immune response during infection and development of T cells and NK cells. In addition to the immunomodulatory functions, IRF1 has also shown to be involved in the regulation of cell cycle progression, tumor suppression, and apoptosis. IRF1-mediated transcription can be repressed by IRF2 through competing for the same binding region on the promoters. |
Immunogen | Partial human IRF1 recombinant protein (147-325 a.a.) |
Other Names | Interferon regulatory factor 1 (IRF-1) |
Gene, Accession # | Gene ID: 3659 |
Catalog # | 332904 |
Price | $370 |
Order / More Info | Human IRF1 Antibody from BIOLEGEND |
Product Specific References | n/a |