PRAS40/AKT1S1 Antibody from BIOLEGEND
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| Antigenic Specificity | PRAS40/AKT1S1 |
| Clone | W22030A |
| Host Species | Rat |
| Reactive Species | human, mouse, rat |
| Isotype | IgG2a, kappa |
| Format | purified |
| Size | 100 µg |
| Concentration | n/a |
| Applications | WB - Quality tested ICC - Verified |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Purified anti-PRAS40/AKT1S1. Numerous growth factors and hormones have the capability to initiate the phosphoinositide 3-kinase signaling pathway, leading to the activation of downstream effector proteins such as the serine/threonine kinase AKT. A 40 kDa proline-rich protein called PRAS40 (also known as AKT1S1), which interacts with 14-3-3 proteins, is one known AKT substrate. In order to transduce AKT signals to the mTOR complex, PRAS40/AKT1S1 interacts with mTOR which regulates cell growth and cell cycle and acts as a negative regulator of autophagy. Inhibition of mTOR signaling promotes PRAS40/AKT1S1 binding to mTOR, which reduces mTOR activity. In PC12 cells, treatment with insulin-like growth factor-1 (IGF1) can cause phosphorylation of PRAS40/AKT1S1 by the PI3K/AKT signaling pathway. In insulin-deficient cells, PRAS40/AKT1S1 interacts with raptor in mTOR complex 1 (mTORC1) and prevents the cell cycle protein Rheb from activating the mTORC1 pathway. The inhibition of mTORC1 by PRAS40/AKT1S1 is relieved when AKT phosphorylates PRAS40/AKT1S1 at Thr246. Additionally, PRAS40/AKT1S1 is phosphorylated on Ser183, Ser212, and Ser221 by mTORC1, which releases it from mTORC1. |
| Immunogen | Recombinant human PRAS40/AKT1S1 protein |
| Other Names | AKT1S1, AKT1 Substrate 1, PRAS40, 40 KDa Proline-Rich AKT Substrate, AKT1 Substrate 1, Proline-Rich AKT1 Substrate 1, MGC2865 |
| Gene, Accession # | Gene ID: 84335 |
| Catalog # | 667652 |
| Price | $415 |
| Order / More Info | PRAS40/AKT1S1 Antibody from BIOLEGEND |
| Product Specific References | n/a |
BIOLEGEND
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