PPP1CA Antibody from BIOLEGEND

Protein phosphatase 1 catalytic subunit alpha (PPP1CA) is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine-specific protein phosphatase involved in the regulation of various cellular processes, such as cell division, glycogen metabolism, muscle contraction, protein synthesis, regulation of membrane receptors and channels, and HIV-1 virus transcription. PP1 has been shown to dephosphorylate RB and CDC25 during mitosis. Cell cycle-dependent phosphorylation at Thr320 of PPP1CA by CDC2 kinase inhibits PPP1CA activity. The studies in human and mice indicate that PP1 is an important regulator of cardiac function, and also show that PP1 suppresses learning and memory in mice.