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Antigenic Specificity | Presenilin 2 |
Clone | PS2 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, κ |
Format | purified |
Size | 100 µg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Purified anti-Presenilin 2. Mutations in the genes for presenilin 1 (PS1) and 2 (PS2) are the causative factors for about 50% of early onset familial Alzheimer?s disease. PS1 and PS2 are homologous transmembrane proteins, and along with nicastrin, form high molecular mass multimeric protein complexes involved in the intramembranous proteolysis of several proteins including amyloid precursor protein (APP) and Notch receptors. Absence of PS1 is associated with dramatic reductions in the levels of mature glycosylated nicastri |
Immunogen | This monoclonal antibody was raised using a GST-fusion containing the complete N-terminal fragment of human Presenilin 2 (residues 1-87). |
Other Names | Presenilin-2, AD5, E5-1, PS-2, AD3LP, STM-2, gamma-secretase, PSEN2, PS2 |
Gene, Accession # | Gene ID: 5664 |
Catalog # | 814204 |
Price | $276 |
Order / More Info | Presenilin 2 Antibody from BIOLEGEND |
Product Specific References | n/a |