Human CD112R (PVRIG) Antibody from BIOLEGEND
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| Antigenic Specificity | Human CD112R (PVRIG) |
| Clone | W16216D |
| Host Species | Rat |
| Reactive Species | human |
| Isotype | IgG2a, kappa |
| Format | TotalSeq™-A oligomer conjugate |
| Size | 10 µg |
| Concentration | n/a |
| Applications | PG - Quality tested |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TotalSeq™-A1454 anti-human CD112R (PVRIG). CD112R gene encodes a single transmembrane protein consisting of a single extracellular IgV domain. Its long intracellular domain contains two tyrosine residues, one of which is within an ITIM-like motif. CD112R was initially named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR/CD155) and polio virus receptor-like (PVRL) genes. CD112R is a cell surface receptor for CD112/Nectin-2, it compete against CD226 in binding to CD112. Following interaction with CD112, CD112R inhibits T-cell proliferation and the disruption of interaction between CD112R and CD112 enhances T cell response. Published studies suggest that CD112R is a novel co-inhibitory receptor, or a checkpoint molecule, that suppressed TCR medicated signal. |
| Immunogen | Human CD112R transfectants |
| Other Names | Poliovirus receptor-related immunoglobulin domain containing protein, PVRIG, C7orf15, CD112 receptor |
| Gene, Accession # | Gene ID: 79037 |
| Catalog # | 301509 |
| Price | $369 |
| Order / More Info | Human CD112R (PVRIG) Antibody from BIOLEGEND |
| Product Specific References | n/a |
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