Description | PE anti-human CD80. CD80, also known as B7-1, B7, and BB1, is a 60 kD single chain type I glycoprotein belonging to the immunoglobulin superfamily. CD80 is expressed on activated B and T cells, macrophages, and dendritic cells. CD80 binds to CD28 and CD152 (CTLA-4). Along with CD86, CD80 plays a critical role in regulation of T cell activation. The interaction of CD80 with CD28 provides a potent costimulatory signal for T cell activation through the CD3 complex, while its interaction with CTLA-4 provides an inhibit |
Product Specific References | PubMed: 21505190, 22904297, 24391212, 24505475, 25895967, 26780292, 27076679, 27122187, 27539532, 27566297, 29302056, 29472691, 30463014, 30719456, 30463014, 30788083, 31753725, 28480794, 31491384, 31757674, 32973772, 31486697 |