Edit |   |
---|---|
Antigenic Specificity | 53BP1 |
Clone | W17184B |
Host Species | Rat |
Reactive Species | human, mouse |
Isotype | IgG2a, κ |
Format | purified |
Size | 25 µg |
Concentration | n/a |
Applications | Western Blot (WB), ICC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Purified anti-53BP1. p53-binding protein 1 (53BP1) was first discovered as an interacting partner of p53 tumor suppressor protein in a yeast two-hybrid screening. 53BP1 binds to p53 through a BRCA1 C-terminal (BRCT) domain and enhances p53-dependent transcriptional activation. 53BP1 has been studied extensively for its function in the regulation of DNA double-strand break (DSB) repair pathway. Additionally, it promotes non-homologous end joining (NHEJ) while inhibiting homologous recombination (HR) by preventing DNA |
Immunogen | Partial recombinant human 53BP1 protein. |
Other Names | Tumor Protein P53 Binding Protein 1, TP53-Binding Protein 1, P53-Binding Protein 1, P53BP1, Tumor Suppressor P53-Binding Protein 1, TDRD30, P202 |
Gene, Accession # | Gene ID: 7158 |
Catalog # | 933001 |
Price | $101 |
Order / More Info | 53BP1 Antibody from BIOLEGEND |
Product Specific References | n/a |