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Antigenic Specificity | Mouse CD152 (CTLA-4) |
Clone | A21140B |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG1, κ |
Format | purified, azide-free, low endotoxin |
Size | 1 mg |
Concentration | n/a |
Applications | Block |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ultra-LEAF™ Purified anti-mouse CD152 (CTLA-4) . Mouse CTLA-4 was initially identified by differential screening of a murine cytolytic cDNA library. It is a member of the IgG superfamily, and it encodes a 223 amino acid protein and possesses a single extracellular V domain, a transmembrane domain, and a cytoplasmic domain. CTLA-4 is about 30% homologous with CD28, and both bind to the same ligands (B7.1/CD80 and B7.2/CD86) although CTLA-4 binds with higher affinity than CD28. Parallel recognition of a specific MHC-peptide complex by the T-cell receptor and CD80 or CD86 by the costimulatory receptor CD28 results in T cell activation, cytokine production, proliferation, and differentiation. After the T cell activation process and upregulation of CTLA-4, co-ligation of the TCR to MHC-peptide complex and CTLA-4 to its ligands results in cell cycle arrest and the end to T cell activation. It has been suggested that the negative regulatory mechanism of CTLA-4 is mediated through trans-endocytosis of CD80 and CD86 (capture of ligands from opposing cells). The ligands are removed from the original cell and degraded inside of CTLA-4-expressing cells. As a result, the action of CD28 is impaired. Alternative splice variants of CTLA-4 have been described in mice and humans; these variants skip exon 2 (ligand-binding domain) or exon 3 (transmembrane domain). The ligand independent CTLA-4 is expressed in mice, but not in humans, and the soluble CTLA-4 (sCTLA-4) is expressed in mice and humans. CTLA-4 is constitutively expressed by Tregs, and they are an important source of sCTLA-4. It has been suggested that sCTLA-4 potentiates regulatory T cell function. High levels of sCTLA-4 in Tregs have been associated with type 1 diabetes (T1D) and other autoimmune diseases. |
Immunogen | Recombinant Mouse CTLA-4-Fc Chimera |
Other Names | Cytotoxic T-lymphocyte protein 4, Otal4, CTLA-4, Cytotoxic T-lymphocyte-associated |
Gene, Accession # | Gene ID: 12477 |
Catalog # | 637754 |
Price | $1145 |
Order / More Info | Mouse CD152 (CTLA-4) Antibody from BIOLEGEND |
Product Specific References | n/a |