Description | Alexa Fluor® 647 anti-mouse/rat/human FOXP3. FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4 /CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in |
Product Specific References | PubMed: 17237431, 20139272, 24316007, 24694524, 25355918, 25958791, 28874690, 29127360, 29526543, 31553906, 29526543, 30611611, 29045906, 29526543, 29882687, 31120033, 31445190, 31553906, 30611611, 32373209, 31523027, 32142650, 31968248, 31523027, 33278358, 32709928, 32499535, 33507149, 33763079, 32738205, 34010637 |