PLCγ1 Antibody from BIOLEGEND

Phospholipase C gamma 1 (PLCγ1) is a signaling enzyme involved in intracellular signal transduction. In response to activation of receptor-type tyrosine kinases, phospholipase C (PLC) enzymes cleave the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into second messengers, namely inositol 1,4,5-triposphate (IP3) and diacylglycerol (DAG). IP3 causes the release of calcium from the endoplasmic reticulum to begin an intracellular signaling cascade, while DAG activates Protein Kinase C.

There are four families of PLCs. The PLCγ family, consisting of PLCγ1 and PLCγ2 in humans, uniquely contains SRC domains SH2 and SH3. Receptor tyrosine kinases interact with these SRC domains to enzymatically activate PLCγ1 via phosphorylation. PLCγ1 is essential for cell proliferation, differentiation, and motility. Overexpression or activation of PLCγ1 has been implicated in breast and prostate cancers as well as cancer cell invasion.