Description | APC anti-mouse CD223 (LAG-3). CD223, also known as LAG-3, is 70 kD type I transmembrane glycoprotein within the Ig superfamily. It is the gene product of lymphocyte activation gene-3 (Lag3) with structural similarity to CD4. CD223 is expressed on activated T cells and NK cells, as well as T regulatory cells. CD223, like CD4, binds MHC class II molecules, but with higher affinity than CD4. In association with the CD3 complex, CD223 has been shown as a negative regulatory molecule to inhibit TCR-mediated signaling and regulate |
Product Specific References | PubMed: 23008449, 26667170, 29848443, 29848443, 30314757, 29221730, 30995478, 30995478, 31031094, 30314757, 29848443, 30580966, 28898698, 29221730, 30314757, 31356173, 31747598, 32582853, 33037113, 33046889, 33852868, 33838102 |