Edit |   |
---|---|
Antigenic Specificity | PTEN |
Clone | W20041H |
Host Species | Rat |
Reactive Species | human |
Isotype | IgG2b, κ |
Format | purified |
Size | 25 µg |
Concentration | n/a |
Applications | Intracellular Staining for Flow Cytometry (ICFC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Purified anti-PTEN. PTEN was discovered as a tumor suppressor with lipid and protein phosphatase activity. Heterozygous loss of PTEN in mice contribute to the development of a variety of types of cancer, suggesting that insufficient PTEN activity results in increased cancer susceptibility. PTEN negatively regulates the PI3K/AKT pathway by dephosphorylating the second messenger phosphoinositide 3,4,5-triphosphate (PIP3) produced by phosphoinositide 3-kinase (PI3K), which results in inhibition of abnormal cell prolif |
Immunogen | Partial recombinant human PTEN protein |
Other Names | BZS, TEP1, PTEN1, PTENbeta, Phosphatase and tensin homolog, MMAC1, CWS1, DEC, GLM2, MHAM |
Gene, Accession # | Gene ID: 5728 |
Catalog # | 366201 |
Price | $147 |
Order / More Info | PTEN Antibody from BIOLEGEND |
Product Specific References | n/a |