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Antigenic Specificity | Human TMPRSS2 |
Clone | S20014A |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, κ |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests |
Concentration | n/a |
Applications | Flow Cytometry (FC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PE anti-human TMPRSS2. TMPRSS2 is a membrane-anchored protein that belongs to the serine protease family and is involved in many physiological and pathological processes. TMPRSS2 participates in proteolytic cascades and is important in normal physiological function of the prostate. Autocleavage leads to secretion of the protease domain. TMPRSS2 is involved in extracellular matrix disruption and metastasis of prostate cancer cells and activates several substrates, including pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14. TMPRSS2 promotes uptake of SARS-CoV-1, MERS-CoV, and SARS-CoV-2 viral particles of by proteolytic cleavage of ACE2 receptor and cleavage of coronavirus spike glycoproteins. |
Immunogen | huTMPRSS2 transfectant |
Other Names | Transmembrane protease serine 2 |
Gene, Accession # | Gene ID: 7113 |
Catalog # | 378404 |
Price | $387 |
Order / More Info | Human TMPRSS2 Antibody from BIOLEGEND |
Product Specific References | n/a |