EGFR Antibody from BIOLEGEND

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Antigenic SpecificityEGFR
CloneA19002A
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1, kappa
FormatPerCP-Cyanine5.5 conjugate
Size25 tests
Concentrationn/a
ApplicationsICFC - Quality tested
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DescriptionPerCP/Cyanine5.5 anti-EGFR. Epidermal Growth Factor Receptor (EGFR) is a receptor tyrosine kinase that links extracellular mitogenic ligand binding to complex downstream signaling cascades. Initial ligand binding results in receptor oligomerization and autophosphorylation of multiple tyrosine residues within cytosolic domains of the the protein. These phosphorylation events stabilize the EGFR kinase activation loop and lead to the recruitment of adaptor proteins and other downstream effectors. EGFR stimulation leads to activation of RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCγ-PKC and STAT signaling cascades, and constitutive activation of the receptor promotes tumorigenesis in multiple cancers.
ImmunogenSynthetic peptide from human EGFR
Other NamesEpidermal Growth Factor Receptor, Receptor Tyrosine-Protein Kinase ErbB-1, Erb-B2 Receptor Tyrosine Kinase 1, ERBB1, NISBD2, PIG61, MENA, Proto-oncogene c-ErbB-1
Gene, Accession #Gene ID: 1956
Catalog #933905
Price$170
Order / More InfoEGFR Antibody from BIOLEGEND
Product Specific Referencesn/a
BIOLEGEND
BIOLEGEND
BIOLEGEND
8999 BioLegend Way
San Diego CA 92121
P: (858) 455-9588
P: 1-877-Bio-Legend (246-5343)
F: (858) 455-9587

customerserv@biolegend.com

http://www.biolegend.com

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