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Antigenic Specificity | EGFR |
Clone | A19002A |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | PerCP-Cyanine5.5 conjugate |
Size | 25 tests |
Concentration | n/a |
Applications | ICFC - Quality tested |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PerCP/Cyanine5.5 anti-EGFR. Epidermal Growth Factor Receptor (EGFR) is a receptor tyrosine kinase that links extracellular mitogenic ligand binding to complex downstream signaling cascades. Initial ligand binding results in receptor oligomerization and autophosphorylation of multiple tyrosine residues within cytosolic domains of the the protein. These phosphorylation events stabilize the EGFR kinase activation loop and lead to the recruitment of adaptor proteins and other downstream effectors. EGFR stimulation leads to activation of RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCγ-PKC and STAT signaling cascades, and constitutive activation of the receptor promotes tumorigenesis in multiple cancers. |
Immunogen | Synthetic peptide from human EGFR |
Other Names | Epidermal Growth Factor Receptor, Receptor Tyrosine-Protein Kinase ErbB-1, Erb-B2 Receptor Tyrosine Kinase 1, ERBB1, NISBD2, PIG61, MENA, Proto-oncogene c-ErbB-1 |
Gene, Accession # | Gene ID: 1956 |
Catalog # | 933905 |
Price | $170 |
Order / More Info | EGFR Antibody from BIOLEGEND |
Product Specific References | n/a |