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Antigenic Specificity | Nitrotyrosine |
Clone | 39B6 |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG2a |
Format | biotin conjugate |
Size | 100 ug |
Concentration | 1 mg/ml |
Applications | AM, ELISA, FC, ICC, IHC, IP, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mouse monoclonal to Nitrotyrosine (Biotin). Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling. While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosino-philperoxidase, myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury. The presence of nitro tyrosine-containing proteins therefore has shown high correlation to disease states such as atherosclerosis, Alzheimers disease, Parkinsons disease and amyotrophic lateral sclerosis.. |
Immunogen | 3-(4-hydroxy-3-nitrophenylacetamido) propionic acid-bovine serum albumin |
Other Names | Nitro tyrosine, 3-Nitrotyrosine |
Gene, Accession # | n/a |
Catalog # | orb147398 |
Price | $585 |
Order / More Info | Nitrotyrosine Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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