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Antigenic Specificity | Beta-Parvin |
Clone | PARVB/8214R |
Host Species | Recombinant Rabbit |
Reactive Species | human |
Isotype | IgG, kappa |
Format | unconjugated |
Size | 100 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Beta-parvin, also known as affixin, is a focal adhesion protein belonging to a family of ILKbinding proteins that contain tandem calponin homolog domains. Along with Alpha-parvin, Beta-parvin is one of the most widely researched and characterized members of this family. These two proteins interact with the ILK kinase domain in a way that is mutually exclusive and regulates both the activity of the kinase and actin cytoskeleton adhesion. Studies have shown Beta-parvin to be downregulated within human breast cancer cells, and that its expression may influence the progression of breast cancer (Johnstone, 2008). Additional research indicates a critical role for Beta-parvin in the regulation of cardiac contractility when it is in complex with ILK (Hannigan, 2007). |
Immunogen | The N-terminal region (residues 1-91) of the human protein was used as the immunogen for the Beta-Parvin antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: Q9HBI1 |
Catalog # | orb1824007 |
Price | $764 |
Order / More Info | Beta-Parvin Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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