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Antigenic Specificity | CDw17 (Lactosylceramide) |
Clone | HuLy-m13 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgM, kappa |
Format | PEG purified |
Size | 20 ug, 100 ug |
Concentration | n/a |
Applications | FACS, IF |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD17/CDw17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. TNFa-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization. |
Immunogen | Beta-2 Microglobulin associated proteins from a detergent lysate of human PBLs were used as the immunogen for the CDw17 antibody. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | orb749936 |
Price | $405 |
Order / More Info | CDw17 (Lactosylceramide) Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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