Cyclin D1 / CCND1 Antibody from BIORBYT LTD.
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| Antigenic Specificity | Cyclin D1 / CCND1 |
| Clone | CCND1/7868 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. |
| Immunogen | A recombinant partial protein (within amino acids 200-295) from the human protein was used as the immunogen for the Cyclin D1 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P24385 |
| Catalog # | orb1826049 |
| Price | $405 |
| Order / More Info | Cyclin D1 / CCND1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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