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Antigenic Specificity | IL22RA2 |
Clone | IL22RA2/7291 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2, kappa |
Format | unconjugated |
Size | 100 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | IL-22RAlpha2 (Interleukin-22 receptor Alpha2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2- soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22RAlpha2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is 4- to 10-fold higher than that of the membrane-bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22RAlpha2 prevents the binding to the IL-22 membrane-bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22RAlpha2 may be important in regulating inflammatory responses. In addition, IL-22RAlpha2 can be induced by lipopolysaccharides (LPSs). |
Immunogen | A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the IL22RA2 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: Q969J5 |
Catalog # | orb1823060 |
Price | $764 |
Order / More Info | IL22RA2 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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