Edit |   |
---|---|
Antigenic Specificity | CHIKV E2 |
Clone | monoclonal |
Host Species | Recombinant Human |
Reactive Species | CHIKV |
Isotype | n/a |
Format | unconjugated |
Size | n/a |
Concentration | n/a |
Applications | IB, ELISA, BL, |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recombinant Human Anti-CHIKV E2 Antibody (CHK265). Recombinant Human Antibody (CHK265) is capable of binding to CHIKV E2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-CHIKV E2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-CHIKV E2 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody bound to CHIKV E2 B domain provided an explanation for its neutralizing activity. Binding to the B domain was associated with repositioning of the A domain of E2 that enabled cross-linking of neighboring spikes. |
Immunogen | Chikungunya virus E2 glycoprotein |
Other Names | E2; E2 glycoprotein; CHIKV; chikungunya virus |
Gene, Accession # | UniProt: Q8JUX5 |
Catalog # | PABL-430 |
Price | please inquire |
Order / More Info | CHIKV E2 Antibody from CREATIVE BIOLABS, INC. |
Product Specific References | n/a |