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Antigenic Specificity | S. aureus Hla |
Clone | monoclonal |
Host Species | Recombinant Human |
Reactive Species | S. aureus |
Isotype | n/a |
Format | unconjugated |
Size | n/a |
Concentration | n/a |
Applications | BL, |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recombinant Human Anti-S. aureus Hla Antibody (MEDI4893). Recombinant Human Antibody (MEDI4893) is capable of binding to S. aureus Hla, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-S. aureus Hla mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-S. aureus Hla proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. MEDI4893 recognizes a novel epitope in the so-called "rim" domain of AT and exerts its neutralizing effect through a dual mechanism. In particular, MEDI4893 not only sterically blocks binding of AT to its cell receptor but also prevents it from adopting a lytic heptameric trans-membrane conformation. |
Immunogen | S. aureus alpha-hemolysin |
Other Names | Hla; alpha-hemolysin; Alpha-toxin; Staphylococcus aureus alpha toxin |
Gene, Accession # | n/a |
Catalog # | PABL-396 |
Price | please inquire |
Order / More Info | S. aureus Hla Antibody from CREATIVE BIOLABS, INC. |
Product Specific References | n/a |