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Antigenic Specificity | HHV-2 gD |
Clone | monoclonal |
Host Species | Recombinant Human |
Reactive Species | HHV |
Isotype | n/a |
Format | unconjugated |
Size | n/a |
Concentration | n/a |
Applications | Neut, |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recombinant Human Anti-HHV-2 gD Antibody (E317). Recombinant Human Antibody (E317) is capable of binding to HHV-2 gD, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HHV-2 gD mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-HHV-2 gD proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The highly inhibitory human monoclonal antibody E317 was previously raised against HSV gD for viral neutralization. E317 directly recognizes the gD-nectin-1 interface and occludes the HVEM contact site of gD to block its binding to either receptor. The binding of E317 to gD also prohibits the formation of the N-terminal hairpin of gD for HVEM recognition. |
Immunogen | n/a |
Other Names | gD; US6; type 1 membrane protein; contains a signal peptide; binds cell surface receptors; involved in cell attachment |
Gene, Accession # | UniProt: Q69467 |
Catalog # | PABC-161 |
Price | please inquire |
Order / More Info | HHV-2 gD Antibody from CREATIVE BIOLABS, INC. |
Product Specific References | n/a |